Aquatic organisms are adapted to an extremely wide range of environments.Physicochemical properties of the biomolecules that work in the tissues and organs of aquatic organisms are significantly different from those of terrestrial animals and plants. We are mainly targeting the muscles of aquatic animals, and are studying to clarify their molecular mechanism of muscle contraction from the viewpoint of comparative physiology and comparative biochemistry. The results obtained are useful not only for accumulating biological knowledge, but also for maintaining the quality of seafood and developing processing technology. In this research field, we will conduct education and research on food science based on the characteristics of aquatic organisms.